Overview
Clinical Benefits
- Rapid antidepressant effects
- Neurogenesis stimulation
- Improved mood and motivation
- Enhanced cognitive flexibility
Administration
Intranasal or subcutaneous injection
Drug class: neurotrophic peptide
Clinical Dosing
Typical dosage
50-200mcg
Starting dose
50mcg
Cadence
Once daily
Full titration schedule
| Phase | Dose |
|---|---|
| Weeks 1-2 | 50mcg daily (intranasal or subcutaneous) |
| Weeks 3+ | 100-200mcg daily, cycle 4 weeks on / 2 weeks off |
Safety Profile
Side effects
- • Headache
- • Nasal irritation (intranasal)
Contraindications
- • Pregnancy
- • Use with SSRIs (caution)
Cycling guidance
Off: 2 wks
Prevents TREK-1 receptor desensitization
Frequently asked questions
PE-22-28 is most commonly researched for: Rapid antidepressant effects, Neurogenesis stimulation, Improved mood and motivation, Enhanced cognitive flexibility.
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Information on this page is for educational purposes only and is not medical advice. Peptides should only be used under the supervision of a qualified healthcare provider.