Overview
Clinical Benefits
- Increases growth hormone and IGF-1
- Improves sleep quality
- Increases muscle mass
- Supports bone density
- Oral administration (no injections)
Administration
Oral — taken by mouth, preferably at bedtime on an empty stomach
Drug class: gh secretagogue
Clinical Dosing
Typical dosage
10-25mg daily
Starting dose
10mg
Cadence
Once daily
Full titration schedule
| Phase | Dose |
|---|---|
| Weeks 1-2 | 10mg once daily (evening/bedtime) |
| Weeks 3-4 | 15mg once daily |
| Weeks 5-8 | 20-25mg once daily (maintenance) |
| Ongoing | Cycle 8-12 weeks on, 4 weeks off recommended |
Safety Profile
Side effects
- • Increased appetite (common)
- • Water retention/bloating
- • Mild lethargy initially
- • Numbness/tingling in hands
- • Elevated blood sugar
Contraindications
- • Diabetes or insulin resistance (monitor glucose closely)
- • Active cancer
- • Pregnancy
- • History of pituitary tumors
Cycling guidance
Off: 4 wks
Prevents IGF-1 desensitization and manages blood sugar impact
Frequently asked questions
MK-677 (Ibutamoren) is most commonly researched for: Increases growth hormone and IGF-1, Improves sleep quality, Increases muscle mass, Supports bone density.
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Information on this page is for educational purposes only and is not medical advice. Peptides should only be used under the supervision of a qualified healthcare provider.