Overview
Clinical Benefits
- Energy + anti-fatigue
- Methylation support
- Nerve regeneration / neuropathy support
- Mood support (methylation-dependent)
- Pairs with B-complex for full mitochondrial support
Administration
Intramuscular injection — deltoid most common
Drug class: vitamin cofactor
Clinical Dosing
Typical dosage
1000mcg per session
Starting dose
1000mcg
Cadence
1x weekly
Full titration schedule
| Phase | Dose |
|---|---|
| Loading (weeks 1-4) | 1000mcg IM weekly |
| Maintenance | 1000mcg IM every 2-4 weeks |
Safety Profile
Side effects
- • Bright pink-red urine (transient)
- • Mild flushing
- • Acne flare in some methylation phenotypes
- • Rare hypersensitivity
Contraindications
- • Cobalt allergy
- • Leber's hereditary optic neuropathy
- • Polycythemia vera
Frequently asked questions
Methylcobalamin (B12) is most commonly researched for: Energy + anti-fatigue, Methylation support, Nerve regeneration / neuropathy support, Mood support (methylation-dependent).
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Information on this page is for educational purposes only and is not medical advice. Peptides should only be used under the supervision of a qualified healthcare provider.