Overview
Clinical Benefits
- UV-independent melanogenesis (tan)
- Libido / sexual response (MC3R/MC4R)
- Appetite modulation
Administration
Subcutaneous injection
Drug class: melanocortin agonist
Clinical Dosing
Typical dosage
250-500mcg daily during load; on-demand for libido
Starting dose
125mcg
Cadence
1x daily (load) → on-demand or weekly (maintenance)
Full titration schedule
| Phase | Dose |
|---|---|
| Day 1 (Trial dose) | 125mcg — MANDATORY. Assess nausea + flushing. |
| Days 2-5 | 250mcg once daily if Day 1 tolerated |
| Days 6-14 (Load) | 500mcg once daily |
| Week 3+ (Maintenance) | 500mcg-1mg once weekly or on-demand for libido |
Safety Profile
Side effects
- • Nausea (mitigated by 125mcg start dose)
- • Flushing
- • Spontaneous erection (research literature)
- • Appetite suppression
- • Increased mole / freckle pigmentation
Contraindications
- • Melanoma history
- • Active dysplastic nevi
- • Pregnancy
- • Uncontrolled cardiovascular disease
Cycling guidance
Off: 8 wks
Loading phase then maintenance; avoid prolonged use
Frequently asked questions
Melanotan II is most commonly researched for: UV-independent melanogenesis (tan), Libido / sexual response (MC3R/MC4R), Appetite modulation.
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