Overview
Clinical Benefits
- UV-independent melanogenesis (tan)
- Photoprotection (research)
Administration
Subcutaneous injection
Drug class: melanocortin agonist
Clinical Dosing
Typical dosage
250-500mcg daily during load; 1mg weekly on maintenance
Starting dose
125mcg
Cadence
1x daily (load) → 1x weekly (maintenance)
Full titration schedule
| Phase | Dose |
|---|---|
| Day 1 (Trial dose) | 125mcg — assess nausea before continuing |
| Days 2-5 | 250mcg once daily if Day 1 tolerated |
| Days 6-14 (Load) | 500mcg once daily |
| Week 3+ (Maintenance) | 1mg once weekly to preserve tan |
Safety Profile
Side effects
- • Nausea (mitigated by 125mcg start dose)
- • Flushing
- • Appetite suppression
- • Increased mole / freckle pigmentation
Contraindications
- • Melanoma history
- • Active dysplastic nevi
- • Pregnancy
Frequently asked questions
Melanotan I is most commonly researched for: UV-independent melanogenesis (tan), Photoprotection (research).
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Information on this page is for educational purposes only and is not medical advice. Peptides should only be used under the supervision of a qualified healthcare provider.