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Weight Management

5-Amino-1MQ

5-Amino-1MQ is a small-molecule NNMT (nicotinamide N-methyltransferase) inhibitor. Blocking NNMT preserves cellular NAD+ pools and reactivates dormant white-adipose lipolysis. Research protocols increasingly favour SubQ delivery (50 mg / mL) for consistent plasma exposure; historical oral capsule route is also viable but has lower bioavailability.

50 mg vialHalf-life: ~8 hoursOnce daily (or AM + PM split)Bioregulator · ≤60 mg/mL
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Overview

Clinical Benefits
  • Increases cellular NAD+
  • Reactivates dormant adipocyte lipolysis
  • Visceral / total-fat reduction
  • Improves metabolic rate
Administration

Subcutaneous injection (primary route). Oral capsule is an alternative delivery for users who cannot inject.

Drug class: nnmt inhibitor

Clinical Dosing

Typical dosage
50mg/day SubQ (or split 2 × 25mg AM/PM)
Starting dose
50mg
Cadence
Once daily (or AM + PM split)
Full titration schedule
PhaseDose
Weeks 1-250mg once daily SubQ (1.0 mL from 50 mg / 1 mL vial), OR split 2 × 0.5 mL AM + PM
Weeks 3-1250mg daily SubQ, maintain single-dose or AM/PM split
Weeks 13+Cycle off 4 weeks

Safety Profile

Side effects
  • • Mild GI upset (oral)
  • • Injection-site tenderness (SubQ)
  • • Limited human trial data
Contraindications
  • • Pregnancy
  • • Liver disease

Frequently asked questions

5-Amino-1MQ is most commonly researched for: Increases cellular NAD+, Reactivates dormant adipocyte lipolysis, Visceral / total-fat reduction, Improves metabolic rate.

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Information on this page is for educational purposes only and is not medical advice. Peptides should only be used under the supervision of a qualified healthcare provider.

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